Journal
TRENDS IN NEUROSCIENCES
Volume 23, Issue 10, Pages 483-490Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(00)01637-4
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Programmed cell death or apoptosis is a common and widespread phenomenon that is important for proper development of the nervous system. In the adult CNS, however, apoptosis contributes to secondary cell loss after various types of lesions. The retino-tectal system has been successfully used as a convenient model system to study the molecular mechanisms of neuronal apoptosis and survival during development and in the lesioned adult CNS. This review describes the current knowledge about the interactions of cell death and survival pathways in general and for retinal ganglion cells specifically.
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