Journal
IMMUNITY
Volume 13, Issue 4, Pages 497-506Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(00)00049-2
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Funding
- NCI NIH HHS [CA 65883] Funding Source: Medline
- NIAID NIH HHS [AI 18757] Funding Source: Medline
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Epstein-Barr virus-infected B cells in vivo demonstrate three distinct patterns of latent gene expression, depending on the differentiation stage of the cell. Tonsillar naive B cells express the EBNA2-dependent lymphoblastoid phenotype, characteristic of direct infection. Germinal center centroblasts and centrocytes as well as tonsillar memory B cells express a more restricted pattern of latent genes (EBNA1(Q-K)(+), LMP1(+), LMP2(+), EBNA2(-)) that has only been seen previously in EBV-positive tumors. Peripheral memory cells express an even more restricted pattern where no latent genes are expressed, with the possible exception of LMP2. These results are consistent with a model where EBV uses the normal biology of B lymphocytes to gain access to and persist within the long-lived memory B cell compartment.
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