Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 36, Issue 8, Pages 1235-1240Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b13-00435
Keywords
pruritogen; spinal receptor; itch sensitization; neuropathic itch
Categories
Ask authors/readers for more resources
The unique physiological features of histamine-sensitive C-fibers and spinothalamic tract neurons support the hypothesis of itch specific pathway, whereas subsequent studies on cowhage-induced itch have provided evidence against it, suggesting the presence of multiple neural pathways for itch. Not only peripheral pruritogens but also spinal neural receptors are involved in the control of itch, and will be the target of treatment. Itch sensitization in chronic pruritus is another crucial factor that needs to be considered in the treatment. Neuropathic itch is the type of itch that occurs when nerve fibers are damaged or injured and spontaneous firing of nerves takes place, and plays a major role in itch accompanying some pathological conditions such as herpes zoster. The complexity of itch is due to the broad range of mediators involved and the large variety of neural mechanisms behind.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available