Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 35, Issue 3, Pages 273-279Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.35.273
Keywords
resveratrol; cyclooxygenase; peroxisome proliferator-activated receptor; endothelial nitric oxide synthase; silent mating type information regulation 2 homolog 1
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [19300250]
- Iijima Memorial Foundation for the Promotion of Food Science and Technology
- Grants-in-Aid for Scientific Research [19300250, 22650173] Funding Source: KAKEN
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Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog I (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in viva evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.
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