Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 35, Issue 4, Pages 515-522Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.35.515
Keywords
hydroxysafflor yellow A; pulmonary inflammation; bleomycin
Categories
Funding
- Traditional Chinese Medicine Development Foundation of Beijing [JJ-2009-22]
- Natural Science Foundation of Beijing [7102025]
Ask authors/readers for more resources
Hydroxysafflor yellow A (HSYA) is an effective ingredient of Chinese herb Carthamus tinctorius L. The aim of this study was to evaluate the protective effect of HSYA on inflammatory phase of bleomycin-induced pulmonary injury in mice. Three doses of FISYA (26.7, 40, 60 mg/kg/d) were intraperitoneally injected to mice consecutively for 1 week after bleomycin administration. It was found that HSYA attenuated the loss in body weight, the increase of myeloperoxidase activity and pathologic changes of pulmonary inflammation caused by bleomycin. Treatment with HSYA also alleviated bleomycin-induced increase of mRNA level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and transforming growth factor (TGF)-beta 1 in lung homogenates. Moreover HSYA inhibited the increased activation of nuclear factor (NF)-kappa B and phosphorylation of p38 mitogen-activated protein kinases (MAPK) in lung tissue. These findings demonstrated that HSYA had protective effect on bleomycin-induced lung inflammatory response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available