Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 10, Issue 5, Pages 607-615Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00138-X
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- NIGMS NIH HHS [GM32707] Funding Source: Medline
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Protein machines and lipid bilayers both play central roles in cell membrane fusion, a process crucial to life. Recent results provide clues to how both components function in fusion. Recent observations suggest a common mechanism by which very different fusion machines (from lipid-enveloped viruses and synaptic vesicles) may function to produce compartment-joining pores. This mechanism presumes that fusion proteins act as machines that use stored conformational energy to assemble closely juxtaposed lipid bilayers, bend these to form fusion-competent structures, stabilize unfavorable lipid structures and destabilize a committed intermediate to drive fusion pore formation.
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