Journal
EXPERIMENTAL PARASITOLOGY
Volume 96, Issue 2, Pages 89-96Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/expr.2000.4556
Keywords
bradyzoite; tachyzoite; Toxoplasma gondii
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Funding
- NIAID NIH HHS [AI41014, AI21423] Funding Source: Medline
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Previous studies have shown the surface of Toxoplasma gondii to be dominated by a family of proteins closely related to SAG1. In this study, we report the existence of a second family of genes defined by homology to SAG2. The predicted amino acid sequences of these three new proteins suggests that they are all glycosylphosphatidylinositol-linked surface antigens. All three also contain N-linked glycosylation sites, although their use has yet to be demonstrated. One of these SAG2-related antigens, SAG2B, is expressed in tachyzoites with an apparent size of 23 kDa. It is distinct, however, from the previously identified P23. In contrast to SAG2B, SAG2C and SAG2D appear to be expressed exclusively on the surface of bradyzoites. Analysis of the SAG2 family shows it to have weak but significant, homology to the SAG1 family. Thus, all of the sequenced surface antigens of tachyzoites and many of those of bradyzoites fall into one large superfamily that can be divided into two subgroups defined by the prototypic and highly immunogenic SAG1 and SAG2, respectively. (C) 2000 Academic Press.
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