Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 18, Issue 3-4, Pages 261-275Publisher
ELSEVIER
DOI: 10.1016/S0927-7765(99)00152-6
Keywords
phosphorylcholine-containing polymers; biomimetic surfaces; protein adhesion resistance; cell adhesion resistance; medical devices
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This article provides an overview of work carried out on the synthesis and non-fouling properties of phosphorylcholine (PC)-containing: polymers. The concept of biomimiery is outlined and the major classes of synthetic PC-based materials described. Studies on the interaction of these materials with various proteins are collated and the mechanism for their protein-resistant nature is discussed. Similarly, cellular interactions are also reviewed, with ex-vivo and in-vivo clinical data provided to demonstrate the usefulness of these materials for improving the properties of medical devices. (C) 2000 Elsevier Science B.V. All rights reserved.
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