Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 34, Issue 1, Pages 13-23Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.34.13
Keywords
human whole saliva; exosome; proteome; dipeptidyl peptidase IV
Categories
Funding
- Japan Science and Technology Agency
Ask authors/readers for more resources
Saliva contains a large number of proteins that participate in the protection of oral tissue. Exosomes are small vesicles (30-100 urn in diameter) with an endosome-derived limiting membrane that are secreted by a diverse range of cell types. We have recently demonstrated that exosomes are present in human whole saliva. In this study, we found that whole saliva contained at least two types of exosomes (exosome I and exosome II) that are different in size and protein composition. Proteomic analysis revealed that both types of exosomes contained Alix, Tsg101 and Hsp70, all exosomal markers, immunoglobulin A and polymeric immunoglobulin receptor, whereas they had different protein compositions. Most of dipeptidyl peptidase IV known as CD26 in whole saliva, was present on the exosome II and metabolically active in cleaving chemokines (CXCL11 and CXCL12). Human whole saliva exosomes might participate in the catabolism of bioactive peptides and play a regulatory role in local immune defense in the oral cavity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available