Journal
NATURE IMMUNOLOGY
Volume 1, Issue 4, Pages 336-341Publisher
NATURE AMERICA INC
DOI: 10.1038/79790
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Funding
- NIAID NIH HHS [AI07313-12, AI35296-06] Funding Source: Medline
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A central tenet of T cell development postulates that if a developing thymocyte encounters self-antigen, it is induced to die via apoptosis, thereby protecting the organism from autoreactive T cells. We created transgenic mice that expressed a peptide antigen in the cortical epithelial cells of the thymus,This did not, however, result in deletion of specific T cells, Instead, antigen presentation by epithelial cells caused T cell receptor (TCR) internalization and increased gene rearrangement at the endogenous TCR alpha locus, or receptor editing,This editing mechanism in immature T cells parallels that which occurs in immature B cells, and has important implications for understanding positive and negative selection signaling in the thymus, and the limits of self-tolerance.
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