Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 33, Issue 2, Pages 238-243Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.238
Keywords
baicalein; baicalin; antiviral activity; serum pharmacology
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Funding
- Qing Lan Project from Jiangsu province
- Ministry of Education of China
- State Administration of Foreign Expert Affairs of China [111-2-07]
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Baicalein, an extract from Scutellaria baicalensis, was evaluated for its ability to inhibit the influenza virus in vivo. Oral administration of baicalein to BALB/c mice infected with the influenza A/FM1/1/47(H1N1) virus showed significant effects in preventing death, increasing the mean time to death, inhibiting lung consolidation, and reducing the lung virus titer in a dose-dependent manner. These effects are believed to be due to baicalin, the metabolite of baicalein in the serum. At a concentration of baicalin 2 mu g/ml in overlay medium, it showed significant inhibition in the plaque assay, and the mean IC50 value of baicalin was calculated as 1.2 mu g/ml in the cytopathic effect assay. Our results showed that baicalein warrants further research as a potential antiinfluenza viral agent.
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