Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 33, Issue 8, Pages 1448-1453Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.1448
Keywords
Artemisia iwayomogi; phenolic compound; iwayomin; osteoblastic MC3T3-E1 cell
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Funding
- Ministry of Education, Science and Technology [2009-0093815]
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One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-beta-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.
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