Journal
DIABETES OBESITY & METABOLISM
Volume 2, Issue 5, Pages 323-325Publisher
WILEY
DOI: 10.1046/j.1463-1326.2000.00090.x
Keywords
very low calorie diet (VLCD); weight loss; insulin resistance; obesity; tumour necrosis factor-alpha; soluble receptors
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The aim of this study was to investigate the variations in the plasma levels of the soluble tumour necrosis factor receptor type-I (sTNFR-I) and type-II (sTNFR-II) during weight loss which was induced by 3 weeks on a very low calorie diet (3.9 +/- 0.1 MJ/day), in 17 non-diabetic obese women. Plasma sTNFR-I concentrations decreased significantly after weight loss (p < 0.05), but there was no significant change in plasma sTNFR-II. As the diet was associated with a significant decrease in body fat mass (approximate to 2.5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity.
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