Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 33, Issue 1, Pages 122-124Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.122
Keywords
melanin; tyrosinase; persimmon; kaki; flavonoid
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We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki 'Fuyu') inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC50: 21.7 and 18.2 mu M, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.
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