Journal
JOURNAL OF ANTIBIOTICS
Volume 53, Issue 10, Pages 1130-1136Publisher
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.53.1130
Keywords
-
Ask authors/readers for more resources
A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available