Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 32, Issue 1, Pages 41-44Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.32.41
Keywords
tryptophan metabolite; allograft; transplantation; methicillin-resistant Staphylococcus aureus; 3-hydroxy-DL-kynurenine
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Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Promotion and Mutual Aid Corporation for Private Schools of Japan
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To study the anti-infectious effect of a vascular allograft, the antimicrobial activity of tryptophan metabolites mediated by indoleamine 2,3-dioxygenase was determined. The growth of methicillin-resistant Staphylococcus aureus (M RSA) over 10 h in extracts from post-transplantation vascular allograft was significantly slower than that of extracts from non-transplantation vascular allograft regardless of the presence of tryptophan (p<0.05). When the antimicrobial activity of the tryptophan metabolites in the L-tryptophaH-L-kynurenine pathway was examined, 3-hydroxy-DL-kynurenine and a-picolinic acid had strong antibacterial activity against MRSA, S. epidermidis, Escherichia coli, and multidrug-resistant Pseudomonas aeruginosa, although antimicrobial activities of anthranilic acid, 3-hydroxyanthranilic acid, and quinolinic acid against them were low. The results showed that, of the tested tryptophan metabolites, 3-hydroxy-DL-kynurenine and alpha-picolinic acid contributed to the anti-infectious effects of the allograft by inhibiting of the growth of microorganisms.
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