Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 115, Issue 4, Pages 740-745Publisher
BLACKWELL SCIENCE INC
DOI: 10.1046/j.1523-1747.2000.00106.x
Keywords
gene therapy; immunotherapy; monoclonal antibody; skin fibroblasts
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In vivo production and systemic delivery of therapeutic antibodies by engineered cells might advantageously replace injection of purified antibodies for treating a variety of life-threatening diseases, including cancer, acquired immunodeficiency syndrome, and autoimmune diseases. We report here that skin fibroblasts retrovirally transduced to express immunoglobulin genes can be used for sustained long-term systemic delivery of cloned antibodies in immunocompetent mice. Importantly, no antiidiotypic response against the ectopically expressed model antibody used in this study was observed. This supports the notion that skin fibroblasts can potentially be used in antibody-based gene/cell therapy protocols without inducing any adverse immune response in treated individuals.
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