Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 11, Issue 8, Pages 309-314Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1043-2760(00)00294-0
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Funding
- NICHD NIH HHS [HD37096, HD35708] Funding Source: Medline
- NIDDK NIH HHS [5 T32 DK07169-21] Funding Source: Medline
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Many of the signal transduction pathways required for mammalian endocrine cel function are conserved from flies and worms. These model organisms permitted the illumination of the biological properties of ligands and provided systems in which cellular coactivating molecules could be identified rapidly. Our knowledge about the activin signaling components has been advanced tremendously by the work carried out in these systems. Subsequent research is beginning to reveal the complex interactions that serve to regulate this signaling pathway.
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