Journal
BIOLOGY OF THE CELL
Volume 92, Issue 7, Pages 477-494Publisher
WILEY
DOI: 10.1016/S0248-4900(00)01101-1
Keywords
focal adhesion; integrins; extracellular matrix; Rho
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Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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