Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 59, Issue 10, Pages 872-879Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/59.10.872
Keywords
DAL-1; hormone receptors; immunohistochemistry; malignant; meningioma; NF2; tumor suppressor gene
Categories
Funding
- NCI NIH HHS [CA777300] Funding Source: Medline
- NINDS NIH HHS [NS35848] Funding Source: Medline
Ask authors/readers for more resources
The molecular pathogenesis of meningiomas is poorly characterized. Loss of NF2 (merlin) expression has been reported in 30%-80% of all sporadic meningiomas. Recently we found that loss of expression for a second Protein 4.1-family tumor suppressor, DAL-I, is also common. A biologically important role for progesterone receptor (PR) has also been proposed based on its reported inverse relationship with tumor grade. In order to better define the pathopenetic roles of these proteins, we studied the merlin, DAL-1, and PR immunoprofiles in 175 fully characterized meningiomas, including nonrecurring versus recurring benign, proliferative versus brain invasive atypical and anaplastic subtypes. Loss of expression for either Protein 4.1-family tumor suppressor (merlin or DAL-1) was almost universal (92%), with combined losses:being common (58%). individually, absence of merlin or DAL-1 protein was detected in 74% and 76% respectively, with no significant differences among the 5 subsets. PR immunoreactivity was commonly associated with retained DAL-1 expression (p < 0.001) and with tumor grade, with 51% of benign, 21% of atypical, and 11% of anaplastic tumors staining positive (p < 0.001). We conclude that PR immunohistochemistry may have diagnostic utility in meningothelial neoplasms. Protein 4.1-family tumor suppressor losses are Likely important early events in meningioma pathogenesis, whereas PR expression is associated with benignity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available