Molecular domains of myelinated axons

Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na+ channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K+ channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junctions in the organization of these domains have emerged.