Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 31, Issue 11, Pages 2146-2149Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.31.2146
Keywords
immunosuppressive therapy; renal transplantation; aging; lymphocyte immunosuppressant-sensitivity test
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Funding
- Kidney Foundation, Japan [JKF 06-3]
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The lymphocyte immunosuppressant-sensitivity test (LIST) has been reported extensively as being able to estimate the pharmacological efficacy of immunosuppressive drugs in individual patients. This stud), measured the IC50 values for 6 drugs, cyclosporine, tacrolimus, methylprednisolone, 6-mercaptopurine, mycophenolic acid, and mizoribine, against mitogen-induced proliferation of peripheral-blood lymphocytes in 29 renal transplant recipients. We also examined relationship between the IC50 values and 4 factors; age, duration of dialysis, percentage of lymphocytes in total white blood cells, and blastogenesis stimulation index by mitogen. There were no significant correlations between the IC50 values and these factors, except that the tacrolimus IC50 value was correlated weakly with the stimulation index (p<0.05, r=-0.429). It was concluded that the pharmacological efficacy of immunosuppressive drugs cannot be inferred from the patient characteristics or their laboratory data. LIST is an effective method to elucidate the pharmacodynamic properties of immunosuppressive agents in individual renal transplant recipients without being influenced by the recipient clinical data.
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