Journal
IMMUNOLOGICAL REVIEWS
Volume 177, Issue -, Pages 236-245Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1600-065X.2000.17610.x
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We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes late, 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such late expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Kruppel-like family of transcription factors. Like RANTES, RFLAT-1 expression is late after T-cell activation. But, unlike RANTES, regulation of RFLAT-1 expression appears to be translational rather than transcriptional.
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