Journal
BEHAVIORAL NEUROSCIENCE
Volume 114, Issue 5, Pages 957-962Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.114.5.957
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Funding
- NICHD NIH HHS [R01 HD033402, HD33402] Funding Source: Medline
- NIDCD NIH HHS [DC03906, R01 DC003906] Funding Source: Medline
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These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenegic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-receptor activation limited to the olfactory bulb (isoproterenol, 50 mu M) displayed a conditioned approach response on subsequent exposure to that odor. Furthermore, putative stimulation of the locus coeruleus (2 mu M idazoxan or 2 mM acetylcholine) paired with odor produced a subsequent preference for that odor. The effects of locus coeruleus stimulation could be blocked by a pretraining injection of the beta-receptor antagonist propranolol (20 mg/kg). Together these results suggest that convergence of odor input with norepinephrine release from the locus coeruleus terminals within the olfactory bulb is sufficient to support olfactory learning.
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