Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 10, Issue 5, Pages 518-527Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00125-1
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Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering longstanding questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are crucial to the expression and regulation of the biological functions of glycosaminoglycans in development and pathophysiology.
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