Journal
GENOMICS
Volume 69, Issue 1, Pages 47-53Publisher
ACADEMIC PRESS INC
DOI: 10.1006/geno.2000.6320
Keywords
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Funding
- NINDS NIH HHS [NS22786] Funding Source: Medline
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Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility. (C) 2000 Academic Press.
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