Journal
INFECTION AND IMMUNITY
Volume 68, Issue 10, Pages 6073-6076Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.10.6073-6076.2000
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Numbers of gamma interferon (IFN-gamma)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-gamma-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.
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