Journal
PLANTA MEDICA
Volume 66, Issue 7, Pages 618-623Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2000-8648
Keywords
Zanthoxylum schinifolium; Rutaceae; root bark; coumarin; terpenyl-coumarins; alkaloids; furoquinolines; antiplatelet aggregation activity; anti-HBV DNA replication
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Further study an the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallyloI (4), hydroxyepoxycollinin ii (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.
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