Journal
BIOSYSTEMS
Volume 58, Issue 1-3, Pages 67-74Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0303-2647(00)00108-8
Keywords
Brownian diffusion model; langevin equations; glutamate; synaptic transmission; hippocampus
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We simulated the diffusion of glutamate, following the release of a single vesicle from a pre-synaptic terminal, in the synaptic cleft by using a Brownian diffusion model based on Langevin equations. The synaptic concentration time course and the time course of quantal excitatory post-synaptic current have been analyzed. The results showed that they depend on the number of receptors located at post-synaptic membrane. Their time course are dependent both on the total number of the post-synaptic receptors and on the eccentricity of the pre-synaptic glutamate vesicle. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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