Journal
NEUROSCIENCE RESEARCH
Volume 38, Issue 2, Pages 217-220Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0168-0102(00)00159-0
Keywords
extracellular matrix; atomic force microscopy; astrocytes; heparan sulfate; proteoglycans; fibril
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Lateral (L) and medial (M) midbrain astrocytes differ in their ability to support neuritic growth (L, permissive; M, non-permissive) with properties of M glia depending on heparan sulfate (HS). Here we show by atomic force microscopy that the surfaces of formaldehyde-fixed astrocytes differ by conspicuous 250 nm protrusions in L and by a HS-dependent fibrillar network in M glia, thus, demonstrating correlations between cell surface morphology and functional properties. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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