Journal
JOURNAL OF NATURAL PRODUCTS
Volume 63, Issue 10, Pages 1447-1448Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np990568p
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Funding
- NCI NIH HHS [CA67786] Funding Source: Medline
- NIGMS NIH HHS [GM07273] Funding Source: Medline
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Cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antifungal activity. CR377, a new pentaketide antifungal agent, was isolated from the culture broth of a fungus, CR377 (Fusarium sp.), that showed potent activity against Candida albicans in this assay. The structure of CR377 was established using 1- and 2-D NMR and HRFABMS.
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