Journal
IUBMB LIFE
Volume 50, Issue 4-5, Pages 245-250Publisher
WILEY
DOI: 10.1080/15216540051080912
Keywords
apoptosis; hydrogen peroxide; mitochondria; nitric oxide; ubiquinone
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Funding
- NIA NIH HHS [1RO1-AG16718] Funding Source: Medline
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Mitochondria are considered the major cellular site for hydrogen peroxide production, a process that is kinetically controlled by the availability of oxygen and nitric oxide to cytochrome oxidase and of ADP to F-1-ATPase, The multisite regulation of mitochondrial respiration and energy-transducing pathways support a critical regulatory role of mitochondrion in cell signaling pathways. The cellular steady-state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed.
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