Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 19, Pages 2159-2161Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00409-1
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Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity st 100 mg/kg dose against sensitive strain. (C) 2000 Elsevier Science Ltd. All rights reserved.
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