Journal
ORGANIC LETTERS
Volume 2, Issue 20, Pages 3229-3231Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol000231a
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- NCI NIH HHS [CA40157] Funding Source: Medline
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[GRAPHICS] Thiol esters and boronic acids do not participate in cross-coupling in the presence of palladium catalysts. However, efficient palladium-catalyzed thiol ester-boronic acid cross-coupling is observed when simple alkylating agents are present. Alkylative conversion of the very stable palladium-thiolate bond to a labile palladium-thioether bond is presumed to be crucial to the catalysis. Of the systems studied, 4-halo-nbutyl thiol esters were most effective in this cross-coupling.
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