Journal
ONCOGENE
Volume 19, Issue 42, Pages 4936-4940Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203861
Keywords
NF-kappa B; Bcl-x; Bfl-1; chemoresistance; chemosensitization
Funding
- NIGMS NIH HHS [GM 08042] Funding Source: Medline
Ask authors/readers for more resources
In A549 human lung adenocarcinoma cells, we found that TNF-alpha and several commonly used chemotherapeutic agents upregulated the expression of Bcl-x and/or Bfl-1/A1 through an NF-kappa B-dependent pathway. While parental A549 cells were resistant to the cytotoxic effects of both TNF-alpha and chemotherapy agents, NF-kappa B-blocked A549 cells were sensitized to both. Expression of either Bcl-x or Bfl-1/A1 in the NF-kappa B-deficient cells at physiological levels provided differential protection against TNF-alpha and chemotherapeutic treatment. These studies provide a potential mechanism for the phenomenon of chemotherapy-induced chemoresistance, and also reveal a potential strategy by which chemoresistance can be overcome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available