Journal
SCIENCE
Volume 290, Issue 5489, Pages 147-150Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5489.147
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- NIA NIH HHS [AG14161] Funding Source: Medline
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An insulinlike signaling pathway controls Caenorhabditis elegans aging. metabolism, and development. Mutations in the daf-2 insulin receptor-like gene or the downstream age-1 phosphoinositide 3-kinase gene extend adult life-span by two- to threefold. To identify tissues where this pathway regulates aging and metabolism, we restored daf-2 pathway signaling to only neurons, muscle, or intestine. Insulinlike signaling in neurons alone was sufficient to specify wild-type life-span, but muscle or intestinal signaling was not. However, restoring daf-2 pathway signaling to muscle rescued metabolic defects, thus decoupling regulation of life-span and metabolism. These findings point to the nervous system as a central regulator of animal longevity.
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