Journal
SCIENCE
Volume 290, Issue 5489, Pages 92-97Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5489.92
Keywords
-
Categories
Ask authors/readers for more resources
The immune response is initiated in organized Lymphoid tissues where antigen-loaded dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of information that must be decoded by the T cell before an appropriate immune response can be mounted. We discuss how the dynamics of DC-T cell encounter and the mechanism of T cell differentiation make the decoding of this information stochastic rather than determinate. This results in the generation of both terminally differentiated effector cells and intermediates that play distinctive roles in,protection, immunoregulation, and immunological memory.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available