Journal
TETRAHEDRON LETTERS
Volume 41, Issue 41, Pages 7983-7986Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01376-9
Keywords
matrix metalloproteinase (MMP); hydroxylamino ring opening; marimastat synthesis
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A considerably shortened synthesis of the broad spectrum matrix metalloproteinase (MMP) inhibitor marimastat has been achieved by a direct hydroxylamino ring opening of a key acetonide intermediate. (C) 2000 Elsevier Science Ltd. All rights reserved.
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