Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 21, Pages 11661-11666Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.21.11661
Keywords
aging; Alzheimer's disease; genetic risk; memory; spatial attention
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Funding
- NIA NIH HHS [AG07569, AG12387] Funding Source: Medline
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The epsilon 4 allele of the apolipoprotein E (APOE) gene is associated with altered brain physiology in healthy adults before old age, but concomitant deficits in cognition on standardized tests of cognitive function have not been consistently demonstrated. We hypothesized that sensitive and specific assessment of basic attentional functions that underlie complex cognition would reveal evidence of impairment in otherwise asymptomatic individuals. We found that as early as middle age, nondemented carriers of the epsilon 4 allele of the APOE gene showed deficits when visual attention was spatially directed by cues in tasks of visual discrimination acid visual search, in comparison to those without the epsilon 4 allele (epsilon 2 and epsilon 3 carriers). Two component attentional operations were selectively affected: (i) shifting spatial attention following invalid location cues, and (ii) adjusting the spatial scale of attention during visual search. These changes occurred only in the presence of the epsilon 4 allele and without decline in other aspects of attention (vigilance), memory, or general cognition. The results show that specific components of visual attention are affected by APOE genotype and that the course of cognitive aging is subject to selective alteration by a genetic trait.
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