Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 21, Pages 11383-11390Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.21.11383
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Funding
- NCI NIH HHS [T32 CA009156, T32 CA09156] Funding Source: Medline
- NHGRI NIH HHS [HG00983] Funding Source: Medline
- NIGMS NIH HHS [R01 GM024110, GM24110] Funding Source: Medline
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In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DsBs). Meiotic DsBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6.200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.
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