Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 277, Issue 1, Pages 195-199Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.3662
Keywords
Flt3; Gab; tyrosine phosphorylation; signal transduction; hematopoietic cells
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Funding
- NHLBI NIH HHS [R01 HL56416] Funding Source: Medline
- NIDDK NIH HHS [R01 DK53674] Funding Source: Medline
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The receptor tyrosine kinase Flt3 has been shown to play an important role in proliferation, differentiation, and survival of hematopoietic stem and progenitor cells. Although some postreceptor signaling events of Fits have been characterized, the involvement of Gab family proteins in Flt3 signaling is not known, In this study, we show that both Gab1 and Gab2 are rapidly tyrosine phosphorylated after Flt3 ligand stimulation of Flt3 ligand-responsive cells. They interact with tyrosine-phosphorylated Shp-2, p85, Grb2, and Shc. The results suggest that Gab proteins are engaged in Flt3 signaling to mediate downstream activation of Shp-2 and PI3 kinase pathways and possibly the Ras/Raf/MAPK pathway. (C) 2000 Academic Press.
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