Journal
LANCET
Volume 356, Issue 9238, Pages 1328-1329Publisher
LANCET LTD
DOI: 10.1016/S0140-6736(00)02823-3
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There is evidence of deterioration of hepatitis C after pregnancy. To investigate potential histological changes, we compared liver biopsy samples taken before and after delivery from 12 women positive for hepatitis C virus (HCV) and 12 non-pregnant HCV-positive women. Semiquantitative histopathological measurements showed greater deterioration In cases than in controls (necroinflammatory score deterioration 83.3% vs 25.0%; fibrosis score 41.6% vs 8.3%). This case-control study suggests that pregnancy may worsen HVCV-related histopathological injury.
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