Journal
GENOMICS
Volume 69, Issue 2, Pages 263-270Publisher
ACADEMIC PRESS INC
DOI: 10.1006/geno.2000.6316
Keywords
-
Funding
- NCI NIH HHS [CA46782] Funding Source: Medline
Ask authors/readers for more resources
We report the identification and characterization of a novel C-type lectin gene, named HECL (HGMW-approved symbol CLECSF7), that maps close to the natural killer gene complex on human chromosome 12p13, Sequence analysis revealed a complete open reading frame of 549 bp comprising several putative glycosylation and phosphorylation sites as well as a C-terminal C-type carbohydrate-recognition domain. Homology analysis revealed that HECL exhibits a significant degree of divergence from the natural killer cell receptors that comprise the natural killer gene complex. These natural killer cell receptors all belong to group V of the C-type lectin superfamily, HECL, however, is most closely related to the sole group II C-type lectins reported to map near this region of the genome, the murine Nkcl and Mpcl genes. Like Nkcl, HECL is expressed in a variety of hematopoietic cell types and has a complete Ca2+-binding site 2, Despite the presence of critical amino acids for sugar binding in Ca2+-binding site 2, HECL does not seem to bind carbohydrate, Moreover, HECL is the first non-receptor-like C-type lectin to map near the natural killer gene complex. (C) 2000 Academic Press.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available