Journal
CANCER LETTERS
Volume 159, Issue 1, Pages 15-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(00)00525-5
Keywords
gastric cancer; loss of heterozygosity; 21q22
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To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in 21q22.3. This data suggests that this locus might harbor a new tumor suppressor gene in an area <0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we speculate that trefoil factor family 1 (TFF1), located in this narrow region, might be the most probable candidate gene involved in gastric cancer carcinogenesis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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