Journal
JOURNAL OF BONE AND MINERAL METABOLISM
Volume 34, Issue 3, Pages 354-365Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00774-015-0681-3
Keywords
Spaceflight; Immobilisation; Bone mineral density; Training; pQCT
Funding
- European Space Agency [14431/02/NL/SH2]
- German Aerospace Center (DLR) [50WB0720]
- Novotec Medical
- Charite Universitatsmedizin Berlin
- Siemens
- Osteomedical Group
- Wyeth Pharma
- Servier Deutschland
- PG
- Kubivent
- Seca
- Astra-Zeneka
- General Electric
- Alexander von Humboldt Foundation
Ask authors/readers for more resources
The impact of effective exercise against bone loss during experimental bed rest appears to be associated with increases in bone formation rather than reductions of bone resorption. Sclerostin and dickkopf-1 are important inhibitors of osteoblast activity. We hypothesized that exercise in bed rest would prevent increases in sclerostin and dickkopf-1. Twenty-four male subjects performed resistive vibration exercise (RVE; n = 7), resistive exercise only (RE; n = 8), or no exercise (control n = 9) during 60 days of bed rest (2nd Berlin BedRest Study). We measured serum levels of BAP, CTX-I, iPTH, calcium, sclerostin, and dickkopf-1 at 16 time-points during and up to 1 year after bed rest. In inactive control, after an initial increase in both BAP and CTX-I, sclerostin increased. BAP then returned to baseline levels, and CTX-I continued to increase. In RVE and RE, BAP increased more than control in bed rest (p a parts per thousand currency sign 0.029). Increases of CTX-I in RE and RVE did not differ significantly to inactive control. RE may have attenuated increases in sclerostin and dickkopf-1, but this was not statistically significant. In RVE there was no evidence for any impact on sclerostin and dickkopf-1 changes. Long-term recovery of bone was also measured and 6-24 months after bed rest, and proximal femur bone mineral content was still greater in RVE than control (p = 0.01). The results, while showing that exercise against bone loss in experimental bed rest results in greater bone formation, could not provide evidence that exercise impeded the rise in serum sclerostin and dickkopf-1 levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available