Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Volume 1482, Issue 1-2, Pages 25-34Publisher
ELSEVIER
DOI: 10.1016/S0167-4838(00)00144-8
Keywords
chromosome; evolution; exon; gene duplication; lipocalin
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Lipocalins exhibit low sequence similarity that contrasts with a tightly conserved folding shared by all members of this superfamily. This conserved folding can be, at least partly, accounted for by a highly conserved gene structure. The array of lipocalin genes that have so far been studied mostly in mammals indicate a large conservation of a typical seven exon/six intron arrangement. Other conserved features include a partly coding exon I of variable size, fixed sizes of exons 2-5 that code for an array of lipocalin-specific beta -strands and a tendency of the last exons to either fuse or expand into further exons without major changes in the length of the resulting open reading frame. The conserved exon/intron arrangement as well as a clustering of most lipocalin genes in given chromosomes of human and mouse indicate that the lipocalin genes diverged from a shared ancestor by successive rounds of duplications followed by late changes in exon arrangements. (C) 2000 Elsevier Science B.V. All rights reserved.
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