4.8 Article

N-benzylhydroxylamine addition to β-aryl enoates.: Enantioselective synthesis of β-aryl-β-amino acid precursors

Journal

ORGANIC LETTERS
Volume 2, Issue 21, Pages 3393-3396

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AMER CHEMICAL SOC
DOI: 10.1021/ol006500e

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[GRAPHICS] Chiral Lewis acid catalyzed N-benzylhydroxylamine addition to pyrrolidinone-derived enoates afforded beta-aryl-beta-amino acid derivatives in high enantiomeric purity with moderate to very good chemical efficiency.

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