Journal
FEBS LETTERS
Volume 483, Issue 2-3, Pages 135-138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02102-5
Keywords
brevinin-1; antimicrobial peptide; amphibian skin
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An extract of skin taken from specimens of the freeze-tolerant wood frog, Rana sylvatica, that were collected from cold (<7C) ponds and maintained at 5 degreesC lacked detectable antimicrobial activity. In contrast, an extract of skin taken from specimens maintained at 30 degreesC for 3 weeks under laboratory conditions contained a high concentration (approximately 4 nmol/g) of a single antimicrobial peptide of the brevinin-1 family (FLPVVAGLAAKVLPSIICAVTKKC). The peptide inhibited growth of Escherichia coli (minimum inhibitory concentration 45 muM) and Staphylococcus aureus (minimum inhibitory concentration 7 muM), The data suggest that synthesis of the peptide is induced when the animal is in an environment that promotes the growth of microorganisms consistent with a role in the animal's defense strategy. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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