Journal
BIOINFORMATICS
Volume 30, Issue 11, Pages 1618-1619Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btu056
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Funding
- Departament d'Innovacio Universitat i Empresa (DIUiE) [2009SGR574]
- Ministerio de Educacion y Ciencia (MEC) [BFU2010-01531, CSD2006-00049]
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BigWig files are a compressed, indexed, binary format for genomewide signal data for calculations (e.g. GC percent) or experiments (e.g. ChIP-seq/RNA-seq read depth). bwtool is a tool designed to read bigWig files rapidly and efficiently, providing functionality for extracting data and summarizing it in several ways, globally or at specific regions. Additionally, the tool enables the conversion of the positions of signal data from one genome assembly to another, also known as 'lifting'. We believe bwtool can be useful for the analyst frequently working with bigWig data, which is becoming a standard format to represent functional signals along genomes. The article includes supplementary examples of running the software.
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