Journal
NEUROREPORT
Volume 11, Issue 15, Pages 3333-3336Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200010200-00014
Keywords
cell death; cerebral ischemia; gerbil; magnetic resonance imaging; microtubule-associated protein 2
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Selective neuronal death of the hippocampal CAI area after mild ischemia is known as delayed neuronal death (DND). Progression of DND was evaluated using 7 T MRI in gerbils. in the CAI, the T2 relaxation time started to increase on day 3 and was significantly higher on day 4 than that of the control gerbils. However, the apparent diffusion coefficient of water (ADC) was significantly lower on day I than in the control and continued to decline up to day 4. Changes in T2 coincided with loss of MAP2 immunoreactivity, while the ADC decrease preceded these changes. After I month, the ADC had returned to within the normal range, while T2 had decreased to below the control level. These results suggest that MRI is useful for monitoring DND. NeuroReport 11:3333-3336 (C) 2000 Lippincott Williams & Wilkins.
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